Neuraxis dissemination in pediatric brain tumors. Response to preirradiation chemotherapy
نویسندگان
چکیده
منابع مشابه
Chemotherapy for brain tumors.
Traditionally, cytotoxic drugs have played a limited role in the treatment of brain tumors, but important advances in chemotherapy have occurred during the past decade. Certain central nervous system (CNS) malignancies are remarkably chemosensitive. These include primary CNS lymphoma, medulloblastoma, oligodendroglioma, and intracranial germ-cell tumors. This review focuses on advances in the c...
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悪性腫瘍 に対す る化学療 法の原則 には3通 りの仮定が あ る.第1は 治癒 するためにはすべての腫瘍 細胞が死滅 し,除 去 され なければな らない とす る説,第2は 生体 に は免疫学 的防御機構 が存 在す るか ら,あ る数 まで腫瘍 細 胞 を減 らす ことができれ ば,あ とは生体 の 自然 に備わ っ た防衛能 力で治癒 す ることができる とす る説,そ して第 3は,悪 性腫瘍 細胞を分化す ることがで きれば,た とえ 腫瘍 細胞が存 在 していて も増殖,転 移 によって生体 に悪 影響 を及ぼす ことな く,正 常組織 と平和共存で きるであ ろ うとする仮説 である.残 念 なが ら今 目,こ の仮説のい ずれが正 しいのか,そ の詳細は不明であ る.現 実的 には 悪性腫瘍 細胞 を減 らすためには5種 類 の治療 方 式 が あ る.す なわち,...
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Primitive neuroectodermal tumors (PNET) of the brain include medulloblastoma (MB) and central nervous system primitive neuroectodermal tumor (CNS PNET) subtypes, which share histological features yet differ at the genomic level and in clinical outcome. Delineation of the genetic anomalies between PNET subtypes is a current challenge for establishing effective targeted therapeutic strategies aga...
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Malignant brain tumors are the most common cause of solid cancer death in children. New targeted therapies are vital to improve treatment outcomes, but must be developed to enable trafficking across the blood brain barrier (BBB). Since activated T cells cross the BBB, cancer immunotherapy can be harnessed to unlock the cytotoxic potential of the immune system. However, standard of care treatmen...
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UNLABELLED Background and Need for Novel Biomarkers: Brain tumors are the leading cause of death by solid tumors in children. Although improvements have been made in their radiological detection and treatment, our capacity to promptly diagnose pediatric brain tumors in their early stages remains limited. This contrasts several other cancers where serum biomarkers such as cancer antigen (CA) 19-...
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ژورنال
عنوان ژورنال: Cancer
سال: 1992
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19920215)69:4<1061::aid-cncr2820690438>3.0.co;2-8